HealthDay operates under the strictest editorial standards. Our syndicated news content is completely independent of any financial interests, is based solely on industry-respected sources and the latest scientific research, and is carefully fact-checked by a team of industry experts to ensure accuracy.
- All articles are edited and checked for factual accuracy by our Editorial Team prior to being published.
- Unless otherwise noted, all articles focusing on new research are based on studies published in peer-reviewed journals or issued from independent and respected medical associations, academic groups and governmental organizations.
- Each article includes a link or reference to the original source.
- Any known potential conflicts of interest associated with a study or source are made clear to the reader.
Please see our Editorial and Fact-Checking Policy for more detail.Editorial and Fact-Checking Policy
HealthDay Editorial Commitment
HeathDay is committed to maintaining the highest possible levels of impartial editorial standards in the content that we present on our website. All of our articles are chosen independent of any financial interests. Editors and writers make all efforts to clarify any financial ties behind the studies on which we report.
MONDAY, June 6, 2022 (HealthDay News) -- An exploratory analysis of data from the SURPASS-4 trial has shown that adults with type 2 diabetes and increased cardiovascular risk receiving tirzepatide experience fewer renal complications, especially new onset of macroalbuminuria; these findings were presented at the annual meeting of the American Diabetes Association, held from June 3 to 7 in New Orleans.
Hiddo L. Heerspink, Ph.D., Pharm.D., from the University Medical Center Groningen in the Netherlands, and colleagues compared progression to prespecified kidney end points between tirzepatide and insulin glargine among 1,995 participants with type 2 diabetes and increased cardiovascular risk.
The researchers found that participants receiving tirzepatide versus insulin glargine experienced significantly fewer renal outcomes, especially new onset of macroalbuminuria (hazard ratio, 0.41). The risk for composite end point 1 (estimated glomerular filtration rate decline ≥40 percent from baseline, renal death, progression to end-stage renal disease, and new onset macroalbuminuria) was significantly lower with tirzepatide (hazard ratio, 0.59).
"With these exploratory findings of SURPASS-4, we are seeing the results of combined gastric inhibitory polypeptide/glucagon-like peptide-1 receptor agonists on the kidney function of patients with type 2 diabetes for the very first time," Heerspink said in a statement. "The findings will be of interest to physicians treating people with diabetes who may have chronic kidney disease."
Several authors disclosed financial ties to pharmaceutical companies, including Eli Lilly, which manufactures tirzepatide and funded the study.
This story may be outdated. We suggest some alternatives.
The content contained in this article is over two years old. As such our recommendation is that you reference the articles below for the latest updates on this topic. This article has been left on our site as a matter of historic record. Please contact us at email@example.com with any questions.
Published on June 06, 2022