Age, Nitrate Use Tied to Phenoconversion With REM Sleep Behavior Disorder

Phenoconversion to α-synuclein-related neurodegenerative disease in patients with idiopathic/isolated REM sleep behavior disorder is 24.2% at three and 67.5% at 10 years. Conversion risk factors were similar for primary dementia and parkinsonism and included older age and nitrate derivative use.

Via Annals of Neurology. Published online January 3, 2022.