Local IgE Response May Indicate Asthma Outcome
IgE level is component of local immune response
FRIDAY, April 20 (HealthDay News) -- Local measures of IgE-mediated responses in the airway may reflect the mucosal immune response and help predict clinical outcome from asthma, according to a report in the April Journal of Allergy and Clinical Immunology.
Silvana Balzar, M.D., from the University of Pittsburgh, and colleagues measured the levels of IgE, IgE receptor and markers of immune cells in tissue samples from 90 subjects with eosinophilic and noneosinophilic severe asthma, mild asthma, or healthy control subjects. The relationship between local and systemic IgE levels and lung function and history of asthma exacerbations was assessed.
By using immunostaining, the investigators found mast-cell bound IgE along the airway that was absent in lung parenchyma. Local/tissue IgE was highest in patients with eosinophilic severe asthma and correlated with number of lymphocytes and eosinophils. Higher local IgE was also linked to better lung function but also more asthma exacerbations.
"Local IgE appears to be primarily a component of responses within the mucosal immune compartment and is related to cellular inflammation, lung function, and clinical outcomes in asthma," the authors wrote. "Local/airway IgE-related processes rather than systemic markers of atopy may be relevant in determining clinical outcomes in asthma."
Some of the authors received grant support from, or are consultants for, Genentech.