See What HealthDay Can Do For You
Contact Us

Nasal Pharyngeal EPX Levels Linked to Sputum Eosinophilia

Strong correlation seen for eosinophil peroxidase levels in adults with poorly-controlled asthma

using asthma inhaler

WEDNESDAY, Dec. 16, 2015 (HealthDay News) -- For individual patients with poorly-controlled asthma, nasal and pharyngeal eosinophil peroxidase (EPX) levels are strongly associated with the eosinophil percentage of induced sputum, according to a study published online Dec. 8 in Allergy.

Matthew A. Rank, M.D., from the Mayo Clinic in Scottsdale, Ariz., and colleagues compared nasal, pharyngeal, and sputum EPX levels with induced sputum eosinophil percentage in 10 adults with poorly-controlled asthma and 10 controls.

The researchers observed a significant difference in sputum EPX levels between asthma and control subjects (P = 0.024). EPX levels measured in nasal and pharyngeal swab samples derived from the same patients were significantly different between asthma and control subjects (each P = 0.002). Compared with induced sputum eosinophil percentage, Spearman's correlation coefficients for nasal EPX and pharyngeal EPX levels were 0.81 (P = 0.0007) and 0.78 (P = 0.0017), respectively.

"There is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum," the authors write. "The use of nasal or pharyngeal swabs may represent a clinically relevant diagnostic metric whose simplicity of use would provide a novel point-of-care assay in the management of asthma patients."

Members of Lee Laboratories reviewed the manuscript.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.