See What HealthDay Can Do For You
Contact Us

Atopic Eczema Patients Often Sensitized to Yeast Strain

Sensitivity to M. sympodialis common and may provide clues to pathogenesis

MONDAY, Nov. 27 (HealthDay News) -- About half of patients with atopic eczema have a sensitivity to the yeast Malassezia sympodialis, according to a report in the November issue of the Journal of Investigative Dermatology.

Barbra Fischer Casagrande, of University Hospital in Zurich, Switzerland, and colleagues evaluated 706 patients using ImmunoCAPm70 and skin-prick tests with crude extracts of M. sympodialis. They also conducted additional tests using recombinant proteins from the yeast.

Overall, 52 of 97 patients (54 percent) had atopic eczema-specific IgE reactivity against M. sympodialis. There was almost no reactivity to M. sympodialis in patients with other allergic conditions (4/571), and no sensitivity in controls. In both extrinsic and intrinsic atopic eczema, IgE and T-cell mediated reactivity was seen.

"Sensitization to M. sympodialis is specific for atopic eczema patients and occurs in both the extrinsic and intrinsic variant of eczema. Recombinant yeast allergens represent a useful tool to study molecular structures and differential sensitization patterns in the pathogenesis of atopic eczema," the authors conclude.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.