PD-1 Expression Tied to Chronic Rhinosinusitis With Nasal Polyps
Higher PD-1 expression in CRSwNP vs nasal tissue from controls; PD-1, IL-5 mRNA expression linked
WEDNESDAY, Feb. 1, 2017 (HealthDay News) -- Programmed cell death 1 (PD-1) expression is associated with chronic rhinosinusitis with nasal polyps (CRSwNP) disease severity, according to a study published online Jan. 25 in Allergy.
Inge Kortekaas Krohn, from the Catholic University of Leuven in Belgium, and colleagues measured expression of PD-1, its ligands PD-L1 and PD-L2, tumor growth factor-β, interleukin (IL)-5, and IL-10 mRNA by real-time polymerase chain reaction on tissue homogenates of 21 patients with CRSwNP and 21 healthy controls and on primary epithelial cells.
The researchers found that compared with controls, patients with CRSwNP had increased PD-1 mRNA expression regardless of the atopy status. PD-1 expression correlated with the total computed tomography scan scores. In control nasal tissue and in CRSwNP, there was a significant association between PD-1 mRNA and expression of IL-5 mRNA. Different subsets of T cells and CD11b dendritic cells had PD-1 expression. Primary epithelial cells from control nasal tissue and nasal polyp tissue had expression of both PD-1 and its ligands.
"Higher PD-1 expression was found in CRSwNP than in nasal tissue from controls," the authors write. "This was associated with disease severity and tissue IL-5 expression but unrelated to the patients' atopy status."