The researchers, including biologists at the University of California, San Diego, found that eliminating the ability of white blood cells to respond to low oxygen levels prevents the development of inflammation in mice.
Their research, which appears in the March 7 issue of Cell, could offer information to assist in the development of new drugs to treat the painful and debilitating joint pain suffered by the 43 million Americans with arthritis.
The finding also may help lead to more effective cancer treatments. In the majority of cases, tumor development is associated with a pronounced inflammatory response.
Here's where you can learn more about arthritis.