Inflammatory Enzymes Linked to Cancer

COX-2 enzymes linked to DNA damage associated with cancer

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TUESDAY, June 15, 2004 (HealthDayNews) -- The first evidence that COX-2 enzymes, which are responsible for pain and inflammation, are also involved in causing DNA damage associated with cancer is outlined in a new University of Pennsylvania study.

This finding provides new insight into how aspirin, along with diets rich in fruits, grains and vegetables, seem to reduce the risk of some cancers. The study also suggests that COX-2 inhibitor drugs, such as the anti-arthritis drugs rofecoxib (Vioxx) and celecoxib (Celebrex), may help prevent the DNA damage caused by COX-2 enzymes.

The research was presented June 15 at the annual meeting of the American Society for Biochemistry and Molecular Biology / 8th International Union of Biochemistry and Molecular Biology Conference in Boston.

The same presentation also included data supporting earlier research that large quantities of vitamin C can increase DNA damage.

More information

The U.S. National Cancer Institute has information about understanding cancer.

SOURCE: Federation of American Societies for Experimental Biology news release, June 15, 2004

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