TUESDAY, July 27, 2004 (HealthDayNews) -- If you've been paying any attention to medical news in the last few years, you've almost certainly heard the word "statins."
You may even have heard this question: "Could statins be the next miracle drug?"
Statins, the marketing term for a group of drugs called HMG-CoA reductase inhibitors -- named for the enzyme whose activity they block -- are most commonly prescribed for their ability to lower levels of LDL cholesterol, the "bad" kind that clogs arteries.
They are extremely effective at this task. Studies have shown that statin therapy can cut a person's LDL levels in blood by between by 25 percent to 35 percent. That translates into a significantly lower risk of heart attack and stroke.
Statins also appear to raise levels of HDL, the "good" cholesterol, too, which further reduces the risk of cardiovascular trouble. And they help the heart and vessels in other ways -- by preventing the breakaway of clot-forming deposits, or plaques, that line diseased arteries, and by relaxing blood vessels, spurring the formation of new vessels and preventing blood clots.
Evidence also indicates that higher doses of statins continue to bring down LDL, which doctors are increasingly coming to recognize as "the lower the better" marker of heart disease risk.
The strength of their cholesterol-busting properties has propelled statins to blockbuster status. In 2000, they were already the world's number two class of prescription drugs, with sales of $15.9 billion, according to IMS Health, a market research group.
And use of statins is expected to increase. U.S. health officials earlier this month issued new guidelines for heart patients to lower their LDL levels to 70, from the previously recommended level of 100.
Still, statins are still considered to be widely under-prescribed, at least for cholesterol.
Roughly 11 million Americans are getting the drugs, while an estimated 36 million should be on them, experts say. More than 200 million people worldwide meet the criteria for statin treatment, yet only 25 million are using the drugs.
Research is showing that statins have beneficial attributes for other health problems, including breast cancer, stroke, bone strength and rheumatoid arthritis.
As encouraging as the research is, statins aren't ready to be added to drinking water. They can cause potentially serious side effects, including a muscle destroying disease called rhabdomyolysis that can be crippling and even deadly if not caught early. Bayer pulled its entry in the statin stakes, in August 2001, after 31 people died of rhabdomyolysis linked to the medication.
Statins also have been known to cause muscle pain and weakness, fatigue, memory and cognitive problems and sleep disturbances. And the drugs may lead to erectile dysfunction and sweats and other trouble regulating body temperature.
And in April, researchers from the U.S. National Institutes of Health reported that statin use by women during the first trimester of pregnancy may increase the chances that their babies will be born with severe central nervous system defects and limb deformities.
More information
To learn more about statins, visit the National Heart, Lung, and Blood Institute.