HealthDay operates under the strictest editorial standards. Our syndicated news content is completely independent of any financial interests, is based solely on industry-respected sources and the latest scientific research, and is carefully fact-checked by a team of industry experts to ensure accuracy.
- All articles are edited and checked for factual accuracy by our Editorial Team prior to being published.
- Unless otherwise noted, all articles focusing on new research are based on studies published in peer-reviewed journals or issued from independent and respected medical associations, academic groups and governmental organizations.
- Each article includes a link or reference to the original source.
- Any known potential conflicts of interest associated with a study or source are made clear to the reader.
Please see our Editorial and Fact-Checking Policy for more detail.Editorial and Fact-Checking Policy
HealthDay Editorial Commitment
HeathDay is committed to maintaining the highest possible levels of impartial editorial standards in the content that we present on our website. All of our articles are chosen independent of any financial interests. Editors and writers make all efforts to clarify any financial ties behind the studies on which we report.
THURSDAY, Feb. 14, 2019 (HealthDay News) -- Exposure to high levels of the pesticide DDT increases breast cancer risk -- but when the cancer surfaces depends on when women first came in contact with the chemical, researchers say.
"What we have learned is that timing really matters," said lead author Barbara Cohn, from the California-based Public Health Institute.
"We know that if harmful exposures occur at times when breast tissue is rapidly changing, such as during puberty, they impact breast development in ways that can later result in cancer," added Cohn.
The breast cancer diagnoses tended to occur about 40 years after exposure to DDT, her team concluded.
DDT was widely used in agriculture until it was banned in the United States in 1972, and banned in many countries in the 1970s. Many women and girls in the United States were exposed to the pesticide. The youngest of them are now reaching the age of increased breast cancer risk.
For this study, researchers looked at more than 15,500 women in California who participated in the institute's Child Health and Development Studies for nearly six decades. Levels of DDT exposure were determined by analyzing stored blood samples taken from them between 1959 and 1967. The researchers analyzed data on breast cancer cases that occurred up until age 54.
All women who were exposed to high levels of DDT had an increased risk of breast cancer through age 54, the study found.
But those exposed to DDT before age 14, particularly in infancy and early childhood, were most likely to develop premenopausal breast cancer (before age 50). Those exposed after infancy were at increased risk of postmenopausal breast cancer (ages 50-54).
Among the specific findings:
- DDT exposure during childhood and puberty (ages 3-13) was a risk factor for both premenopausal and postmenopausal breast cancer.
- A doubling of DDT was associated with an almost tripled increased risk of postmenopausal breast cancer for those first exposed to the pesticide after infancy.
- Women at increased risk for premenopausal breast cancer were first exposed to DDT in utero and during infancy through puberty, but not after age 14. The highest risk was associated with first exposure before age 3.
- Women first exposed to DDT after age 14 only had an increased risk of breast cancer after menopause, and were not at increased risk for breast cancer before age 50.
"The research suggests that DDT affects breast cancer as an endocrine disruptor, that the period of time between first exposure and cancer risk seems to be around 40 years -- and that other endocrine-disrupting chemicals could potentially simulate this kind of risk pattern," Cohn said in an institute news release.
Considering the patterns observed, working backward to determine when a woman first came into contact with DDT could help aid early detection and treatment of DDT-associated breast cancer, Cohn added.
The study was published Feb. 13 in the Journal of the National Cancer Institute.
The U.S. National Cancer Institute has more on breast cancer.
This story may be outdated. We suggest some alternatives.
The content contained in this article is over two years old. As such our recommendation is that you reference the articles below for the latest updates on this topic. This article has been left on our site as a matter of historic record. Please contact us at firstname.lastname@example.org with any questions.
Updated on May 27, 2022