Predicting the Prognosis for Prostate Cancer Patients

Biomarker strong predictor of outcome for those with disease

Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. And "More information" links may no longer work. Questions about personal health should always be referred to a physician or other health care professional.

TUESDAY, Oct. 21, 2003 (HealthDayNews) -- The presence of a biomarker called Ki-67 may be a significant predictor of outcome for prostate cancer patients treated with both hormones and radiation, say researchers at Fox Chase Cancer Center in Philadelphia.

When a tumor cell tests positive for Ki-67, which is a proliferation antigen, that means the tumor is actively growing.

Previous smaller studies by the Fox Chase scientists found the greater the proportion of prostate tumor cells with Ki-67, the more aggressive the cancer. Those previous studies involved small patient numbers and didn't conclusively establish the usefulness of the Ki-67 biomarker.

"Our (new) study conclusively shows that Ki-67 was the most significant determinant of distant metastasis and death in prostate cancer patients," Dr. Alan Pollack, chairman of radiation oncology at Fox Chase, says in a prepared statement.

"The relationship of Ki-67 to patient outcome is a continuous function, wherein the higher the per cent of Ki-67, the greater the risk of adverse result. In addition, Ki-67, along with PSA, Gleason score and stage, appears to be valuable in determining whether high-risk patients may be spared long-term androgen deprivation," Pollack says.

The study was presented Oct. 21 at the annual meeting of the American Society for Therapeutic Radiology and Oncology in Salt Lake City.

More information

Here's where you can learn more about prostate cancer.

SOURCE: Fox Chase Cancer Center, news release, Oct. 21, 2003


Last Updated: