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Gender Affects Outcome in Percutaneous Procedures

Adverse events more common in women treated for non-ST-elevation acute coronary syndromes

WEDNESDAY, Dec. 6 (HealthDay News) -- Women who undergo percutaneous coronary intervention for non-ST-elevation acute coronary syndromes (NSTACSs) have a higher risk of major adverse cardiac events than their male counterparts and also a higher risk than men or women undergoing percutaneous coronary intervention for stable angina, researchers report in the December issue of the American Journal of Cardiology.

Ruchira Glaser, M.D., of the University of Pennsylvania in Philadelphia, and colleagues evaluated 4,919 consecutive patients (1,800 women and 3,119 men). Among the women, 1,338 underwent percutaneous coronary intervention for NSTACS and 462 for stable angina. Among the men, 2,124 underwent percutaneous coronary invention for NSTACS and 995 for stable angina.

The researchers found that women with NSTACS had a significantly higher one-year rate of death/myocardial infarction/cardiac rehospitalization than men with NSTACS (37.6 percent versus 29.8 percent). But they found only a marginal difference in one-year rates of adverse events in women and men with stable angina (29.4 percent versus 27.7 percent, respectively).

"It is worth noting that differences in adverse event rates between women and men were present by one year despite similar, excellent acute procedural success rates; the reasons for this finding are unclear," the authors write. "Although it is possible that sicker women are referred for percutaneous coronary intervention compared with men, differences persisted after adjustment for differences in previously well-described co-morbidities."

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