Aortic Stenosis May Be Linked to Atherosclerosis

Aortic stenosis hastened in those with metabolic syndrome

MONDAY, June 12 (HealthDay News) -- Aortic stenosis progresses more quickly in patients who also have metabolic syndrome, suggesting that aortic stenosis is an active process mediated by many of the same factors that influence atherosclerosis, according to a report in the June 6 issue of the Journal of the American College of Cardiology.

Philippe Pibarot, Laval Hospital Research Center in Sainte-Foy, Quebec, Canada, and colleagues retrospectively analyzed data from 105 patients with an average age of 69 years who had at least moderate aortic stenosis, to examine its association with metabolic syndrome.

The researchers found that metabolic syndrome was a strong predictor of both stenosis progression and disease-free survival. Hemodynamic progression of stenosis was twice as fast in patients with metabolic syndrome compared with those without the disease (-0.14 cm2/year versus -0.08 cm2/year, respectively). Moreover, the three-year event-free survival was much lower among those with metabolic syndrome.

It has been suggested that aortic stenosis is caused by an atherosclerotic process and, therefore, may be influenced by the atherogenic features of metabolic syndrome. "This is the first study to report that metabolic syndrome is highly prevalent in patients with aortic stenosis and that it is a strong and independent predictor of disease progression and occurrence of adverse outcomes," the authors conclude.

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