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Two Types of Heart Disease Imaging Complementary

Scan identifies atherosclerosis while perfusion imaging detects ischemia

THURSDAY, Dec. 14 (HealthDay News) -- Multi-slice computed tomography (MSCT) and myocardial perfusion imaging (MPI) play complementary roles in providing information about coronary artery disease, according to study findings published in the Dec. 19 issue of the Journal of the American College of Cardiology.

Jeroen J. Bax, M.D., Ph.D., of Leiden University Medical Center in the Netherlands, and colleagues conducted a study of 114 patients, most of whom had intermediate likelihood of coronary artery disease, and who all underwent both MSCT and MPI. The results of the MSCTs were classified as showing no coronary artery disease, non-obstructive coronary artery disease with less than 50 percent luminal narrowing, or obstructive coronary artery disease. The MPI results were classified as showing either normal or abnormal results. Invasive coronary angiography was performed in a subset of 58 patients.

A total of 41 patients (36 percent) had no coronary artery disease based on the MSCT data, of whom 90 percent had normal MPI. Thirty-three patients (29 percent) had non-obstructive coronary artery disease and 40 patients (35 percent) had at least one significant lesion. Among the patients with abnormal MSCT results, only 45 percent had abnormal MPI; and 50 percent of those with an obstructive coronary artery disease result from the MSCT had a normal MPI. The correlation with MSCT was 90 percent in those undergoing angiography.

"MPI and MSCT provide different and complementary information on coronary artery disease, namely, detection of atherosclerosis versus detection of ischemia," the authors conclude. "As compared to invasive angiography, MSCT has a high accuracy for detecting coronary artery disease in patients with an intermediate likelihood of coronary artery disease."

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