Urinary BPA Increased in Severe Coronary Artery Disease
Bisphenol A exposure significantly higher in those with severe CAD versus normal arteries
FRIDAY, Aug. 17 (HealthDay News) -- Bisphenol A (BPA) exposure, as measured by urinary BPA (uBPA) concentrations, is higher in individuals with severe coronary artery disease (CAD) compared to those with no vessel disease, according to a study published online Aug. 15 in PLoS One.
David Melzer, M.B., Ph.D., from the University of Exeter in the United Kingdom, and colleagues compared uBPA with grades of severity of CAD on angiography using data from 591 patients participating in the Metabonomics and Genomics in Coronary Artery Disease study.
The researchers found that 385 patients had severe (one to three vessel) CAD, 86 had intermediate disease, and 120 had normal coronary arteries. Median uBPA concentration (unadjusted) was 1.28 ng/mL for those with normal coronary arteries and 1.53 ng/mL for those with severe CAD. Concentration of uBPA was significantly higher in those with severe CAD compared to those with normal coronary arteries (odds ratio, 1.43; P = 0.033), and near significant for intermediate disease (odds ratio, 1.69; P = 0.061). There was no significant difference in uBPA between the group of patients with severe CAD who required surgery and the remaining groups combined.
"In our relatively small sample of patients investigated for ischemic heart disease referred for coronary angiography, BPA exposure (evident in uBPA concentrations) was higher in those with severe coronary artery stenoses compared to those with no vessel disease," the authors write. "Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established."