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Endometriosis Tied to Elevated Risk of Coronary Heart Disease

Hysterectomy/oophorectomy and earlier age at surgery associated with increased risk of CHD

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TUESDAY, March 29, 2016 (HealthDay News) -- Laparoscopically confirmed endometriosis is associated with increased subsequent risk of coronary heart disease (CHD), according to a study published online March 29 in Circulation: Cardiovascular Quality and Outcomes.

Fan Mu, Sc.D., from Brigham and Women's Hospital in Boston, and colleagues assessed the correlation between laparoscopically confirmed endometriosis and subsequent CHD. The correlation was assessed among 116,430 women from the Nurses' Health Study II, excluding those with a history of heart disease and stroke.

The researchers found that women with laparoscopically confirmed endometriosis had a higher risk of myocardial infarction, angiographically confirmed angina, coronary artery bypass graft surgery/coronary angioplasty procedure/stent, or any of these CHD outcomes combined (relative risks, 1.52, 1.91, 1.35, and 1.62, respectively), compared to women without endometriosis. These findings were independent of potential demographic, anthropometric, family history, reproductive, and lifestyle confounding variables. Women aged ≤40 years had the highest relative risk for the combined CHD end point (relative risk, 3.08), which decreased with increasing age. The risk of combined CHD was elevated for those having had a hysterectomy/oophorectomy (relative risk, 1.51). Overall, 42 percent of the correlation between endometriosis and CHD was attributable to greater frequency of hysterectomy/oophorectomy and earlier age at surgery after endometriosis diagnosis.

"These data have implications for clinical management of endometriosis patients, suggesting that women with endometriosis may represent a high-risk group for CHD," the authors write.

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