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Peripheral Arterial Disease Linked to Higher Mortality

Condition independently predicts death after percutaneous coronary procedures

THURSDAY, Oct. 19 (HealthDay News) -- Concomitant peripheral arterial disease is linked with higher mortality after percutaneous coronary intervention and myocardial infarction, and independently predicts short- and long-term death rates, according to research in the Oct. 17 issue of the Journal of the American College of Cardiology.

Jacqueline Saw, M.D., of the University of British Columbia in Vancouver, Canada, and colleagues performed a pooled analysis of 19,867 patients who had percutaneous coronary intervention, 1,602 of whom had peripheral arterial disease. The researchers used multivariable analysis to examine seven- and 30-day outcomes and six-month and one- year events.

Peripheral arterial disease was linked to higher mortality or myocardial infarction at all time points, and showed a trend towards an increased risk of major bleeding. The authors found peripheral arterial disease significantly predicted mortality at 30 days (hazard ratio, 1.67), six months (hazard ratio, 1.76) and one year (hazard ratio, 1.46).

"The presence of peripheral arterial disease is associated with higher rates of post-percutaneous coronary intervention death and myocardial infarction, and is an independent predictor of short- and long-term mortality," the authors conclude.

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