Mitral Annular Calcification Associated with CVD in Elderly
Patients with mitral annular calcification have worse profile than those with aortic annular calcification or aortic valve sclerosis
THURSDAY, Jan. 5 (HealthDay News) -- Of the three types of calcification commonly found in the free-living elderly -- mitral annular calcification (MAC), aortic annular calcification (AAC) and aortic valve sclerosis (AVS) -- MAC has the strongest association with cardiovascular disease (CVD), according to a study in the January issue of the American Heart Journal.
Eddy Barasch, M.D., of St. Francis Hospital in Roslyn, N.Y., and colleagues used two-dimensional echocardiography to evaluate MAC, AAC, AVS and all three combined in 3,929 subjects with a mean age of 76 years.
The researchers identified MAC in 1,640 (42%) subjects, AAC in 1,710 (44%), AVS in 2,114 (54%) and all three combined in 662 (17%). They found that the MAC subjects had a worse cardiovascular, renal, metabolic and functional profile than those with AAC or AVS. Using an age-, sex- and race-adjusted logistic regression analysis, the investigators found a significant association between the three calcification categories and CVD, the strongest being between the combined group with congestive heart failure (OR: 2.04). Using highly adjusted models, however, they found that only MAC was associated with CVD.
"Future work is needed to determine whether AAC or the combination of all three calcification categories also mediates a higher risk for incident cardiovascular events," the authors conclude.