Peptide Predicts Mortality Risk After Heart Failure

Risk higher regardless of systolic function and other variables

TUESDAY, May 8 (HealthDay News) -- A high level of B-type natriuretic peptide after heart failure predicts a higher risk of death, regardless of systolic function and other variables, according to study findings published online April 30 in the Journal of the American College of Cardiology.

Gregg C. Fonarow, M.D., from the University of California Los Angeles, and colleagues measured the levels of B-type natriuretic peptide, or BNP, in 48,629 patients hospitalized for acute decompensated heart failure within 24 hours of presentation. The risk of mortality was determined based on BNP quartile: Q1 (less than 430 pg/mL), Q2 (430-839 pg/mL), Q3 (840 to 1,729 pg/mL) and Q4 (1,730 pg/mL or more).

The researchers found that in-hospital mortality increased from the lowest to highest quartile, ranging from 1.9 to 6 percent. BNP quartile independently predicted mortality regardless of whether left ventricular systolic function was preserved and even after adjusting for variables such as age, gender and systolic blood pressure, with an adjusted odds ratio of 2.23 comparing the highest and lowest quartiles.

"An elevated admission BNP level is a significant predictor of in-hospital mortality in acute decompensated heart failure with either reduced or preserved systolic function, independent of other clinical and laboratory variables," Fonarow and colleagues conclude.

The study was funded by Scios, Inc. of Mountain View, Calif.

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