Non-Fasting Triglyceride Levels Predict Cardiac Events

Two studies suggest elevated non-fasting triglyceride levels associated with coronary heart disease

TUESDAY, July 17 (HealthDay News) -- Elevated non-fasting triglyceride levels are a risk factor for coronary heart disease, according to two reports published in the July 18 issue of the Journal of the American Medical Association.

Borge Nordestgaard, M.D., of Herlev University Hospital in Herlev, Denmark, and colleagues followed 7,587 women and 6,394 men in Copenhagen for about 26 years. For women, adjusted myocardial infarction hazard ratios increased from 1.7 for triglyceride levels between 1 and 2 mmol/L (relative to levels below 1 mmol/L), to 5.4 for levels above 5 mmol/L; for men, the hazard ratios increased from 1.4 to 2.4. Hazard ratios for ischemic heart disease ranged from 1.4 to 2.6 in women, and from 1.1 to 1.5 in men. For total death, the hazard ratios for women ranged from 1.3 to 3.3, and from 1.2 to 1.8 in men.

Paul Ridker, M.D., of Brigham and Women's Hospital in Boston, and colleagues studied 26,509 healthy American women for about 11 years, and also found that increasing non-fasting triglyceride levels correlated with as much as a twofold increased likelihood of cardiac events, even after adjusting for a variety of risk factors. Fasting triglyceride levels, however, were not associated with increased risk.

"The data from both studies in this issue suggest that women have greater risk associated with hypertriglyceridemia than men, as has been suggested, but the risk of elevated postprandial triglyceride levels increase risk for both sexes," note the authors of an accompanying editorial.

Some of the authors of these studies report receiving research support and consulting honoraria from several pharmaceutical companies.

Abstract -- Nordestgaard
Full Text -- Nordestgaard (subscription or payment may be required)
Abstract -- Ridker
Full Text -- Ridker (subscription or payment may be required)

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