Genes May Determine BP Medication Effect

Gene region on chromosome 2 a promising area of research

TUESDAY, Sept. 27 (HealthDay News) -- A gene region located on chromosome 2 may influence the response to antihypertensive drugs, according to a study presented at the American Heart Association's annual high blood pressure research meeting in Washington, D.C.

Sandosh Padmanabhan, Ph.D., a specialist registrar at the British Heart Foundation in Glasgow, and colleagues collected data on 2,142 severely hypertensive white patients.

Among the subjects in the study, 89 sibling pairs did not respond to ACE inhibitors and beta blockers and 76 pairs did not respond to calcium channel blockers and diuretics. Padmanabhan's team analyzed DNA samples and using genome-wide linkage analysis, they found a region on chromosome 2 that appears to be involved in causing high blood pressure in people who do not respond to ACE inhibitors and beta blockers.

"The locus on chromosome 2p in a subset of Caucasian hypertensives unresponsive to ACE inhibitors and beta blocker drugs coincides with a linked region identified in African American hypertensives," they conclude. "This suggests that the region may contain a gene for the salt-sensitive form of hypertension and/or a pharmacogenetic locus affecting drug response."

Abstract (P.36)

Physician's Briefing