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Periodontal Disease, hs-CRP Synergistic in Hypertension

Have effect on urine albumin-to-creatinine ratio in untreated adults with hypertension

TUESDAY, Feb. 1 (HealthDay News) -- In middle-aged adults with untreated hypertension, high-sensitivity C-reactive protein (hs-CRP) and periodontal disease have a synergistic effect on levels of urine albumin-to-creatinine ratio (UACR), according to a study published in the January issue of The American Journal of Cardiology.

Costas Tsioufis, M.D., of Hippokration Hospital in Athens, Greece, and colleagues assessed 242 middle-aged patients with untreated hypertension for periodontal disease, and evaluated their UACR and serum hs-CRP level. The severity of periodontal disease was evaluated by the mean clinical loss of attachment, maximum probe depth, and gingival bleeding index.

The researchers found that the patients with high UACR had significantly higher 24-hour systolic blood pressure compared to those with low UACR. UACR was determined by hs-CRP, all periodontal disease indexes, and the interaction of hs-CRP with each periodontal disease index. They found that the strongest determinant of the high-UACR/high-hs-CRP pattern among all studied periodontal disease indexes was mean clinical loss of attachment. The researchers concluded that periodontal disease indexes and hs-CRP have a synergistic effect on UACR levels in this patient population regardless of underlying hemodynamic load.

"The present study suggests that hypertensive patients with increased UACR could constitute potential candidates for periodontal disease assessment and, in contrast, those with periodontitis should be counseled to measure their blood pressure and possibly undergo microalbuminuria estimation," the authors write.

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