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Uncontrolled Hypertension More Common in the South

Second study explores role of medication non-adherence on blood pressure control

MONDAY, Feb. 11 (HealthDay News) -- A new study explores geographic patterns of uncontrolled hypertension in the United States, while findings from another study suggest that antihypertensive medication non-adherence plays a key role in uncontrolled hypertension. The research is published online Feb. 11 in Circulation: Journal of the American Heart Association and Archives of Internal Medicine, respectively.

Majid Ezzati, Ph.D., of Harvard School of Public Health in Boston, and colleagues analyzed data from two national surveys -- the National Health and Nutrition Examination Survey (NHANES) and Behavioral Risk Factor Surveillance System (BRFSS) -- in order to estimate state trends in systolic blood pressure. The researchers found between 2001-2003, the prevalence of age-adjusted uncontrolled blood pressure was highest among several southern states, and in all states, uncontrolled hypertension was more common in women than men.

In a second study, P. Michael Ho, M.D., of Denver Veterans Affairs Medical Center, and colleagues studied data from 10,447 patients with coronary disease from a managed care organization to investigate the association of medication non-adherence and intensification of antihypertensive therapy on blood pressure control. The researchers report that intensification of drug therapy (odds ratio 1.31) and medication non-adherence (odds ratio 1.73) were both associated with uncontrolled blood pressure compared with high blood pressure that become controlled over time.

"These findings suggest that medication non-adherence can help explain why blood pressure levels remained elevated despite intensification of antihypertensive medications. Successful blood pressure control is seen with a combination of intensification and adherence, suggesting that therapy intensification must be coupled with interventions to enhance medication adherence," Ho and colleagues conclude.

Abstract - Ezzati
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Abstract - Ho
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