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Aspirin Reduces Platelet Aggregation After Laser Therapy

Aggregation reduced by 58 percent in animal study

FRIDAY, Oct. 27 (HealthDay News) -- Treatment of platelet-rich plasma with aspirin can reduce platelet aggregation by 58 percent after high-energy excimer laser treatment, according to a study in animals in the October issue of Lasers in Surgery and Medicine.

George S. Abela, M.D., from Michigan State University in East Lansing, and colleagues examined whether aspirin could reduce platelet aggregation when using a laser during arterial revascularization procedures. Aspirin was added (final concentration 0.2 mg/mL) or omitted from the platelet-rich plasma of seven rabbits followed by irradiation with a high-energy excimer laser. Platelet aggregation was measured by laser-light scattering.

The investigators found that the aspirin-treated plasma had a mean platelet volume of only 43.1 cubic micrometers after irradiation compared with 102.2 cubic micrometers in untreated plasma. The baseline volume was 3.4 cubic micrometers in both cases, according to the study.

"Aspirin reduces large platelet aggregates but not small aggregates by 58 percent during lasing of platelet-rich plasma," Abela and colleagues conclude.

The study was partially funded by Spectranetics Corporation in Colorado Springs, Colo.

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