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Apolipoprotein Levels Predict Coronary Heart Disease Risk

But such measurements offer no incremental utility over the ratio of total cholesterol to HDL-C

TUESDAY, Aug. 14 (HealthDay News) -- Although serum levels of some apolipoproteins are as predictive of coronary heart disease as traditional lipids, they do not provide any extra risk-prediction value over established risk factors such as the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, researchers report in the Aug. 15 issue of the Journal of the American Medical Association.

Ramachandran S. Vasan, M.D., of the Framingham Heart Study in Framingham, Mass., and colleagues studied 3,322 middle-aged white subjects who were free of cardiovascular disease in 1987-1991. During a median 15-year follow-up, 291 of the subjects developed coronary heart disease.

After adjusting for non-lipid risk factors, the researchers found that the apo B:apo A-I ratio predicted coronary heart disease per standard deviation increment in both men (hazard ratio, 1.39) and women (HR, 1.40). But they found that these risk ratios were comparable to, but not better than, those for total cholesterol:HDL-C ratios in men (HR, 1.35) and women (HR, 1.36).

"These data do not support measurement of apo B or apo A-I in clinical practice when total cholesterol and HDL-C measurements are available," the authors conclude.

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