Brain Natriuretic Peptide Predicts Valvular Disease Outcome

In severe aortic stenosis, both logistic EuroSCORE and brain natriuretic peptide predict mortality

TUESDAY, Sept. 16 (HealthDay News) -- Both the calculated logistic EuroSCORE (logES) and an elevated brain natriuretic peptide (BNP) predict mortality in patients with symptomatic aortic stenosis, researchers report in the September issue of the American Journal of Cardiology.

Giovanni Battista Pedrazzini, M.D., of Cardiocentro Ticino in Lugano, Switzerland, and colleagues compared the prognostic value of BNP and the logES in predicting short- and long-term outcomes in patients with symptomatic aortic stenosis undergoing aortic valve replacement.

At study completion, the perioperative mortality was 6 percent and the overall mortality was 13 percent, the researchers report. Patients with a logES and BNP in the upper tertile were 2.86 and 9.01 times more likely to die during the study, respectively. In bivariate analysis, BNP, but not logES, independently predicted death, and a BNP plasma level greater than 312 pg/mL better discriminated survivors from non-survivors compared to logES.

"This study showed for the first time that the preoperative BNP plasma level has a comparable and even better value than the logES in predicting long-term mortality in symptomatic patients undergoing valve replacement due to aortic stenosis," the authors write. "However, both BNP and logES can be considered as markers of the overall severity of the disease, as both are directly (logES) or indirectly (BNP) related to a series of risk factors."

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