WEDNESDAY, June 30 (HealthDay News) -- Among adult congenital heart disease patients with Fontan physiology, the prevalence of chronic venous insufficiency (CVI) is high, according to a study published in the July 6 issue of the Journal of the American College of Cardiology.
Anne Marie Valente, M.D., of Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues prospectively evaluated 159 adults with Fontan physiology for lower extremity CVI, and compared them with age- and sex-matched controls.
The researchers found that the prevalence of CVI was significantly greater in the Fontan group than healthy controls (60 versus 32 percent). In addition, the prevalence of severe CVI, defined as clinical, etiological, anatomical, and pathophysiological grade ≥4, was significantly higher in the Fontan group than healthy controls (22 versus 0 percent). In multivariate analysis, the researchers also found that increased numbers of catheterizations with groin venous access, lower extremity itching, and deep venous thrombosis were independently associated with severe CVI.
"CVI is common in adult congenital heart patients with Fontan physiology and is often severe. The occurrence of CVI in other populations of adults with congenital heart disease, as well as the contribution of abnormal peripheral hemodynamic conditions in adult survivors with Fontan palliation to comorbidities including thromboembolism and heart failure, and interventions to improve peripheral hemodynamics require further exploration," the authors write.