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Coenzyme Predicts Heart Failure Mortality

Survival independently predicted by coenzyme Q10

THURSDAY, Oct. 23 (HealthDay News) -- Plasma coenzyme Q10 (CoQ10) concentration independently predicts mortality and may serve as a marker for the long-term prognosis of chronic heart failure, according to a report published in the Oct. 28 issue of the Journal of the American College of Cardiology.

Sarah L. Molyneux, Ph.D., of the University of Otago in Christchurch, New Zealand, and colleagues examined the association of CoQ10 with survival among 236 patients hospitalized with chronic heart failure. Plasma samples of total CoQ10 were obtained at admission.

The median age of participants was 77 years with a median CoQ10 concentration of 0.68 μmol/L and an optimal CoQ10 concentration for prediction of mortality of 0.73 μmol/L, the report indicates. Multivariable analysis adjusted for covariates demonstrated CoQ10 was an independent predictor of survival, the investigators found.

"No previous studies, however, have formally studied the relationship between CoQ10 and outcomes in chronic heart failure in a longitudinal observational study such as ours," the authors comment. "Our findings in a clearly defined, prospectively studied group that CoQ10 depletion is associated with worse outcomes in chronic heart failure give further support to the rationale of the intervention studies that have already been initiated."

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