Exercise Cuts Known Risk Factors for Heart Disease

Blood pressure, hemostatic and inflammatory factors most affected risk factors

WEDNESDAY, Oct. 24 (HealthDay News) -- Exercise leads to a decline in heart disease risk due to its effect on well-known risk factors such as inflammation and blood pressure, researchers report in the Nov. 6 issue of Circulation: Journal of the American Heart Association.

Samia Mora, M.D., of Brigham and Women's Hospital in Boston, and colleagues analyzed baseline blood levels of inflammatory and hemostatic biomarkers, novel lipids, traditional lipids, low-density lipoprotein, total cholesterol and hemoglobin A1c in 27,055 apparently healthy female study subjects, and data the women volunteered on diabetes, hypertension, height, weight and exercise.

After a mean follow-up of 10.9 years, there were 979 cardiovascular disease episodes reported. Physical exercise was linked to significantly decreased cardiovascular disease risk. The researchers found an exercise-related cardiovascular disease reduction from effects on hemoglobin A1c and diabetes (8.9 percent), body mass index (10.1 percent), novel lipids (15.5 percent), traditional lipids (19.1 percent), blood pressure (27.1 percent), inflammatory and hemostatic biomarkers (32.6 percent).

"The inverse association between physical activity and cardiovascular disease risk is mediated in substantial part by known risk factors, particularly inflammatory/hemostatic factors and blood pressure," the authors write.

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