Gender and Advanced Heart Failure Outcome Not Related

No outcome differences based on gender in patients with advanced decompensated heart failure

TUESDAY, Aug. 19 (HealthDay News) -- Overall, outcomes for men and women with advanced decompensated heart failure (ADHF) are similar with some differences based on heart failure etiology, according to an article published in the Aug. 15 issue of the American Journal of Cardiology.

Wilfried Mullens, M.D., of the Cleveland Clinic in Ohio, and colleagues examined 278 consecutive patients with ADHF to determine if there were gender-specific differences in clinical presentation, response to intensive medical therapy, and outcomes in patients treated in a dedicated heart failure intensive care unit.

While there were significantly more men in the cohort (226 versus 52) and non-ischemic causes of ADHF were more prevalent among women, mortality and rehospitalization rates were similar between genders, the researchers report. Significant improvement in hemodynamic status was noted independent of gender and, likewise, no significant treatment differences in therapy at admission, during intensive medical therapy or at discharge were seen, the report indicates. However, compared to men, the investigators found women with ischemic cardiomyopathy had higher all-cause mortality rates (50 percent versus 37 percent) and those with non-ischemic cardiomyopathy had lower all-cause mortality rates (19 percent versus 40 percent).

"The key clinical implication was that guideline-recommended care was well-tolerated by women and can be safely administered to achieve significant hemodynamic improvement," the authors conclude. "Our study clearly indicated that overall hemodynamic improvement after intensive medical treatment was similar, if not greater, in women than men."

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