Genes Linked to Cognitive Decline Post Heart Surgery

Variants of two inflammatory genes reduce risk of cognitive decline

MONDAY, May 7 (HealthDay News) -- Variants of two genes involved in inflammation reduce the risk of cognitive decline after coronary artery bypass graft surgery, according to a report published online April 30 in the Journal of the American College of Cardiology.

Joseph P. Mathew, M.D., from Duke University Medical Center in Durham, N.C., and colleagues genotyped 513 patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass with a panel of 37 single-nucleotide polymorphisms (SNPs). Cognitive deficit was tested six weeks later.

The researchers found a reduced risk of postoperative cognitive deficit in patients with minor frequency alleles of the C-reactive protein 1059G/C SNP (odds ratio 0.37) and the SELP 1087G/A SNP (OR, 0.51). This translated into a reduction in absolute risk of 20.6 percent and 15.2 percent, respectively. Platelet activation and levels of C-reactive protein were significantly lower in these patients, the study notes.

"The results suggest a contribution of P-selectin and C-reactive protein genes in modulating susceptibility to cognitive decline after cardiac surgery, with potential implications for identifying populations at risk who might benefit from targeted perioperative anti-inflammatory strategies," Mathew and colleagues conclude.

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