Ibuprofen May Interfere With Aspirin's Cardiac Benefits

Physicians should advise patients on timing of the two medications

WEDNESDAY, Sept. 13 (HealthDay News) -- Patients who are taking low-dose aspirin for its cardioprotective effects should be advised on ways to reduce interference from concomitant use of ibuprofen, according to the U.S. Food and Drug Administration. Patients taking immediate release aspirin, (i.e., not enteric coated) can avoid interference if they take a single dose of 400 mg of ibuprofen at least 30 minutes after ingestion or more than eight hours after ingestion of aspirin, the FDA says.

Currently available information is insufficient to judge the impact of ibuprofen in patients taking enteric-coated low-dose aspirin.

Because the antiplatelet effect of low dose aspirin is long-lasting, it is unlikely that occasional use of ibuprofen causes more than minimal risk of attenuation of its effects.

However, given that the clinical implications of ibuprofen interference with aspirin's cardioprotective effects, the FDA recommends physicians prescribe analgesics that do not interfere with aspirin in high-risk populations.

The FDA recommends that other over-the-counter, non-steroidal anti-inflammatory drugs (NSAIDs) be viewed as also having the potential to interfere with aspirin's antiplatelet effect.

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