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Metabolic Syndrome Linked to Cardiovascular Risk, Death

Association highest in women, studies with low-risk individuals

MONDAY, Jan. 22 (HealthDay News) -- Patients with metabolic syndrome are indeed at increased risk for cardiovascular events and death, according to a systematic review and meta-analysis published in the Jan. 30 issue of the Journal of the American College of Cardiology.

Apoor Gami, M.D., and colleagues from the Mayo Clinic College of Medicine in Rochester, Minn., reviewed 37 studies comprising 43 cohorts -- including a total of 172,573 individuals -- to assess the association between metabolic syndrome and incident cardiovascular events and death.

Metabolic syndrome was associated with a 1.78 relative risk for these outcomes and further increased to 2.63 when considering only women. The association with cardiovascular events and death was also stronger in studies enrolling low-risk individuals and studies using the World Health Organization criteria for identifying metabolic syndrome.

"The best available evidence suggests that people with metabolic syndrome are at increased risk of cardiovascular events," the authors write. "These results can help clinicians counsel patients to consider lifestyle interventions, and should fuel research of other preventive interventions."

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