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Metabolic Syndrome Raises Salt Sensitivity of Blood Pressure

In patients with multiple risk factors, reduced salt intake may help lower blood pressure

MONDAY, Feb. 16 (HealthDay News) -- Metabolic syndrome is significantly associated with salt sensitivity of blood pressure, according to a report published online Feb. 16 in The Lancet.

Jing Chen, M.D., of Tulane University School of Medicine in New Orleans, and colleagues studied 1,906 non-diabetic Chinese subjects aged 16 and older who received a low-sodium diet for seven days followed by a high-sodium diet for seven days. Of the 1,881 subjects with information regarding metabolic syndrome, 283 had metabolic syndrome.

On both the low-sodium and high-sodium diets, the researchers found that subjects with metabolic syndrome had significantly greater multivariable-adjusted mean changes in blood pressure. Compared to subjects with no risk factors for metabolic syndrome, they found that subjects with four or five risk factors were significantly more likely to have high salt sensitivity during the low-sodium and high-sodium diets (odds ratios, 3.54 and 3.13, respectively).

"These results suggest that metabolic syndrome enhances blood pressure response to sodium intake," the authors conclude. "Reduction in sodium intake could be an especially important component in reducing blood pressure in patients with multiple risk factors for metabolic syndrome."

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