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Metabolic Syndrome Tied to Doubled Risk of CV Outcomes

Individuals with syndrome also have increased risk of all-cause mortality

TUESDAY, Sept. 21 (HealthDay News) -- Individuals with metabolic syndrome have a doubled risk of cardiovascular outcomes and a 58 percent higher risk of all-cause mortality, according to a meta-analysis published in the Sept. 28 issue of the Journal of the American College of Cardiology.

Salvatore Mottillo, of McGill University in Montreal, and colleagues performed a systematic review and meta-analysis including 87 studies with 951,083 patients. Studies used the 2001 National Cholesterol Education Program and 2004 revised National Cholesterol Education Program definitions for metabolic syndrome.

The researchers found that, with the definitions pooled, metabolic syndrome was associated with a higher risk of cardiovascular disease (relative risk [RR], 2.35), cardiovascular disease mortality (RR, 2.40), all-cause mortality (RR, 1.58), myocardial infarction (RR, 1.99), and stroke (RR, 2.27). Even without diabetes, patients with metabolic syndrome had a high cardiovascular risk.

"Our systematic review identified an important gap in the literature; studies are needed to investigate whether or not the prognostic significance of the metabolic syndrome exceeds the risk associated with the sum of its individual components," the authors write. "We recommend that health care workers use the metabolic syndrome to identify patients who are at particularly high risk for cardiovascular complications. The prevention and reduction of the metabolic syndrome is essential to reduce cardiovascular disease and to extend life in the adult population."

A co-author disclosed financial relationships with Merck and AstraZeneca.

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