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Risk Score Predicts Bleeding in Acute Coronary Syndromes

Identifies patients at risk for non-CABG-related bleeding and subsequent mortality

WEDNESDAY, June 2 (HealthDay News) -- Researchers have developed and tested a practical risk score designed to predict the risk and implications of major bleeding in acute coronary syndromes (ACS), and have found it effective for identifying at-risk patients, according to research published in the June 8 issue of the Journal of the American College of Cardiology.

Roxana Mehran, M.D., of the Columbia University Medical Center in New York City, and colleagues studied 17,421 patients with ACS to develop a practical risk score to predict the risk and implications of major bleeding in that population.

The researchers found non-coronary artery bypass graft surgery (CABG)-related bleeding within 30 days in 744 patients (7.3 percent), and it had six baseline predictors and one treatment-related variable. The integer risk score differentiated patients who had a 30-day rate of non-CABG-related major bleeding with a range of 1 to more than 40 percent. In addition, major bleeding independently predicted a 3.2-fold increase in mortality.

"Patients with ACS have marked variation in their risk of major bleeding. A simple risk score based on six baseline measures plus anticoagulation regimen identifies patients at increased risk for non-CABG-related bleeding and subsequent one-year mortality, for whom appropriate treatment strategies can be implemented," the authors conclude.

The Medicines Company and Boston Scientific provided funding for the studies the researchers used in their analysis but not for the analysis itself. Several authors disclosed financial ties to these and other pharmaceutical and medical device companies.

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