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Stent Fracture A Common Cause of In-Stent Restenosis

Variety of factors may be responsible for stent damage

FRIDAY, Aug. 24 (HealthDay News) -- Stent fracture is one of the most common causes of in-stent restenosis in patients with sirolimus-eluting stents, according to a report in the Aug. 15 issue of the American Journal of Cardiology.

Sang-Hee Lee, M.D., of Yeung-nam University Hospital in Daegu, Korea, and colleagues analyzed findings from 366 patients who had received sirolimus-eluting stents and had later returned for follow-up angiography.

The investigators found that 26 patients had developed in-stent restenosis. Out of this group, the researchers discovered stent fractures in 10 patients. Five patients had an avulsion-type fracture (defined as two fractured segments completely separated, or stent struts missing from the fracture site); two patients had collapse fracture (folded and compacted stent walls in a bended segment of the device) and three had partial fracture (missing stent struts in at least one-third of the vessel wall).

"We cannot conclude that any one factor is the key element for stent fracture after sirolimus-eluting stent implantation. However, we speculate that multiple factors, including poor neointimal hyperplasia, stent design and cardiac movement, contribute to the development of stent fracture," the authors write.

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