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Temporal hs-cTnT Increase Linked to Risk of CHD, CHF

Temporal increases in high-sensitivity cardiac troponin T over six years linked to increased risks

heart illustration

THURSDAY, June 9, 2016 (HealthDay News) -- Temporal increases in high-sensitivity cardiac troponin T (hs-cTnT) are associated with increased risk of coronary heart disease (CHD), heart failure, and all-cause mortality, according to a study published online June 8 in JAMA Cardiology.

John W. McEvoy, M.B., B.Ch., from the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues conducted a prospective observational cohort study involving 8,838 participants with biracial representation who had hs-cTnT measured twice, six years apart. During a maximum of 16 years, the author examined the correlation between hs-cTnT change and subsequent CHD, heart failure, and death.

The researchers observed independent correlations for incident detectable hs-cTnT with subsequent CHD (hazard ratio [HR], 1.4), heart failure (HR, 2.0), and death (HR, 1.5), relative to an hs-cTnT level <0.005 ng/mL at both visits. Among individuals with the most marked hs-cTnT increases, the HRs were as high as 4.0 for CHD and death and 8.0 for heart failure. Among those with relative hs-cTnT reductions greater than 50 percent from baseline, the risk for subsequent outcomes was lower. Inclusion of information on hs-cTnT change improved discrimination for heart failure and death in a model that included traditional and other risk factors.

"Serial determination of hs-cTnT trajectory adds clinically relevant information to baseline testing and may be useful in prognostic assessments and the targeting of prevention strategies to high-risk individuals," the authors write.

Several authors disclosed financial ties to Roche Diagnostics, which donated reagents for the assays.

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