Three-Year Outcomes Similar in Men, Women Given Stents

Both genders have decreased revascularization rate with drug-eluting versus bare-metal stents

TUESDAY, July 21 (HealthDay News) -- Women and men have similar three-year outcomes following coronary stent placement, according to research published in the July issue of the Journal of the American College of Cardiology: Cardiovascular Interventions.

Yoshinobu Onuma, M.D., of Erasmus Medical Center in Rotterdam, Netherlands, and colleagues analyzed data from 4,936 patients (1,394 women) who underwent percutaneous coronary intervention, 2,131 of whom received bare-metal stents and 2,805 of whom received drug-eluting stents.

The researchers found that women were on average five years older than men and more often had diabetes and hypertension, and they had percutaneous coronary intervention less often for acute myocardial infarction. In patients with either stent type, genders had similar rates of all-cause death, myocardial infarction, target vessel revascularization, and stent thrombosis during the three years after the procedure. The authors further note that patients treated with drug-eluting stents had lower rates of target vessel revascularization and major adverse cardiac events compared to bare-metal stents.

"It has been shown that the macrovasculature and microvasculature are stiffer and smaller and that there is more endothelial and smooth muscle dysfunction in women than in men. There are also data to suggest that estrogen attenuates the vessel wall response to injury, in part by reducing the rate of oxidative degradation of arterial wall nitric oxide and by promoting prostatcyclin formation and vasodilation," writes the author of an accompanying editorial.

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