WEDNESDAY, Feb. 2 (HealthDay News) -- Marked weight loss after gastric bypass surgery (GBS) is associated with reversal of unfavorable cardiac remodeling and improved left and right ventricular function, according to a study published in the Feb. 8 issue of the Journal of the American College of Cardiology.
Theophilus Owan, M.D., from the University of Utah School of Medicine in Salt Lake City, and colleagues prospectively studied 423 severely obese patients who underwent GBS, and 733 severely obese patients who did not have surgery. Patients were followed over a two-year period, and the impact on cardiac geometry and function was assessed.
The investigators found that patients who underwent GBS had a significantly larger reduction in their body mass index (BMI) compared to controls. Patients who underwent GBS had reductions in their left ventricular mass index and right ventricular cavity area. Left atrial volume was not affected in GBS subjects, but increased in controls. GBS subjects had increased left ventricular midwall fractional shortening and right ventricular fractional area change. Several factors were independently associated with left ventricular mass index, including age, change in BMI, and severity of nocturnal hypoxemia; but surgical status, change in waist circumference, and change in insulin resistance were not.
"In this large prospective study, we found that marked weight loss occurring via GBS was associated with stabilization or partial reversal of the major geometric and functional cardiac changes associated with severe obesity," the authors write.
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