AHA: Statins Not Associated With Increased Cancer Risk

Diagnosis of any cancer for up to 10 years does not differ between statin and non-statin users

WEDNESDAY, Nov. 17 (HealthDay News) -- Patients undergoing treatment with statins do not appear to be at an increased risk of cancer due to their statin use, according to research presented at the American Heart Association's Scientific Sessions 2010, held from Nov. 13 to 17 in Chicago.

To determine whether cancer can be attributed to statin use among a general population of older adults in the United States, Claudio Marelli, of S2 Statistical Solutions Inc. in Cincinnati, and colleagues evaluated more than 11 million patient records from January 1990 through February 2009 from the GE Centricity electronic medical records database. Propensity score methods matched 45,857 comparison pairs of statin users and non-statin users.

Prior to matching, the investigators found that cancer occurred in 11.7 percent of statin users and in 11.0 percent of non-statin users. After matching, the incidence of cancer in statin patients declined to 11.37 percent compared to 11.11 percent among matched non-statin patients. The investigators also found that Kaplan Meier curves for diagnosis of any cancer showed no difference for statin and non-statin users for up to 10 years.

"This analysis of nearly 46,000 propensity-matched pairs demonstrated no statistically significant increased risk of cancer associated with statins," the authors conclude.

Several authors disclosed financial relationships with various medical device companies and other commercial organizations.

Abstract No. 23153
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