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Black Race Independent Predictor of Stent Thrombosis

Black patients more likely to experience stent thrombosis after drug-eluting stent implantation

MONDAY, Aug. 30 (HealthDay News) -- Black race is a distinct risk factor for developing stent thrombosis (ST) after drug-eluting stent (DES) implantation, according to a study published online Aug. 30 in Circulation.

Sara D. Collins, M.D., of the Washington Hospital Center in Washington, D.C., and colleagues studied 1,594 black patients and 5,642 non-black patients who underwent DES implantation between April 2003 and December 2008.

The investigators found that the incidence of early ST at 30 days was 1.71 percent among blacks and 0.59 percent among non-blacks, and the incidence of late ST at 12 months was 2.25 percent among blacks and 0.79 percent among non-blacks. At 24 months, the incidence of late ST was 2.78 percent among blacks and 1.09 percent among non-blacks, and at 36 months it was 3.67 percent among blacks and 1.25 percent among non-blacks. In addition, the rate of all-cause death was 24.9 percent in black patients and 13.1 percent in non-black patients at 36 months. After adjustment for multiple variables, including median income and clopidogrel compliance, black race was found to be a strong predictor of late ST.

"Because our analysis adjusts for traditional variables associated with racial disparities in health care, further mechanisms such as genetic polymorphisms and responsiveness to antiplatelet therapy must be pursued," the authors write.

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