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Mouse Stem Cells Point to Regenerative Human Therapy

Induced pluripotent stem cells show heart potential similar to embryonic cells

MONDAY, May 5 (HealthDay News) -- Induced pluripotent stem cells from mice have the potential to differentiate into cells of the cardiovascular and hematopoietic lineages similar to that of embryonic stem cells, according to research published online May 1 in the journal Stem Cells.

Katja Schenke-Layland, Ph.D., of the University of California Los Angeles, and colleagues found that induced pluripotent stem (iPS) cells from iPS cell-derived chimeric mice differentiated in vivo into cardiomyocytes, smooth muscle cells, endothelial cells and hematopoietic cells. After researchers triggered differentiation in iPS cells via two approaches -- embryoid body formation and exposure to collagen type IV -- the resulting cells expressed cardiovascular and hematopoietic markers.

Analysis of these differentiated cells revealed Flk1-positive progenitor cells, the researchers report. When these collagen type IV-differentiated progenitor cells were isolated by magnetic cell sorting, they demonstrated the potential to differentiate into functional smooth muscle cells, endothelial cells, hematopoietic cells and cardiomyocytes, the report indicates.

"Regardless of…uncertainties, direct reprogramming of somatic cells to generate patient-matched pluripotent stem cells has the potential to address many of the current limitations and could revolutionize the treatment of many diseases. The development of efficient, reliable and easily reproducible differentiation protocols for generating human iPS cell-derived cardiovascular and hematopoietic progenitor cells will facilitate the development of patient-tailored cardiovascular and hematopoietic regenerative therapies," the authors conclude.

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