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Vitamin D, Coronary Heart Disease Link Varies by Race

Low concentrations of 25(OH)D linked to increased risk of CHD for whites, Chinese

Vitamin D, Coronary Heart Disease Link Varies by Race

TUESDAY, July 9 (HealthDay News) -- Low concentrations of serum 25-hydroxyvitamin D (25[OH]D) are associated with an increased risk of coronary heart disease (CHD) among whites and Chinese, but not among blacks or Hispanics, according to a study published in the July 10 issue of the Journal of the American Medical Association.

Cassianne Robinson-Cohen, Ph.D., from the University of Washington in Seattle, and colleagues examined the correlation between serum 25(OH)D concentration and the risk of CHD in a multiethnic cohort (6,436 adults). Participants were free of cardiovascular disease at baseline from July 2000 through September 2002, and were followed through May 2012.

During a median follow-up of 8.5 years, the researchers identified 361 participants with an incident CHD event (7.38 events per 1,000 person-years). The correlation between 25(OH)D and CHD differed significantly by race/ethnicity. Lower 25(OH)D concentrations correlated with increased risk of incident CHD among whites (hazard ratio, 1.26) and Chinese (hazard ratio, 1.67) for each 10-ng/mL decrease in 25(OH)D. For black and Hispanic participants there was no correlation between 25(OH)D and risk of CHD.

"Our study suggests that the risks and benefits of vitamin D supplementation should be evaluated carefully across race and ethnicity, and that the results of ongoing vitamin D clinical trials should be applied cautiously to individuals who are not white," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

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