Vitamin D, Coronary Heart Disease Link Varies by Race
Low concentrations of 25(OH)D linked to increased risk of CHD for whites, Chinese
TUESDAY, July 9 (HealthDay News) -- Low concentrations of serum 25-hydroxyvitamin D (25[OH]D) are associated with an increased risk of coronary heart disease (CHD) among whites and Chinese, but not among blacks or Hispanics, according to a study published in the July 10 issue of the Journal of the American Medical Association.
Cassianne Robinson-Cohen, Ph.D., from the University of Washington in Seattle, and colleagues examined the correlation between serum 25(OH)D concentration and the risk of CHD in a multiethnic cohort (6,436 adults). Participants were free of cardiovascular disease at baseline from July 2000 through September 2002, and were followed through May 2012.
During a median follow-up of 8.5 years, the researchers identified 361 participants with an incident CHD event (7.38 events per 1,000 person-years). The correlation between 25(OH)D and CHD differed significantly by race/ethnicity. Lower 25(OH)D concentrations correlated with increased risk of incident CHD among whites (hazard ratio, 1.26) and Chinese (hazard ratio, 1.67) for each 10-ng/mL decrease in 25(OH)D. For black and Hispanic participants there was no correlation between 25(OH)D and risk of CHD.
"Our study suggests that the risks and benefits of vitamin D supplementation should be evaluated carefully across race and ethnicity, and that the results of ongoing vitamin D clinical trials should be applied cautiously to individuals who are not white," the authors write.
Two authors disclosed financial ties to the pharmaceutical industry.