Patching Device Repairs Hole in Heart

Ventricular septal defects are rare but potentially deadly

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By
HealthDay Reporter

THURSDAY, May 10, 2007 (HealthDay News) -- Emergency use of a patching device can help patients avoid high-risk surgery when a heart attack tears a hole between the ventricles, the lower blood-pumping chambers of the heart, researchers report.

"These patients often are too ill to go to surgery at once," explained Dr. Matthew W. Martinez, a cardiology fellow at the Mayo Clinic in Rochester, Minn. "What we are doing is bridging these people so that they become stable enough to survive surgery."

These types of dangerous cardiac tears, called a "ventricular septal defect", are fortunately rare and occur in less than 1 percent of heart attacks, according to Martinez. However, drug treatment leaves patients with a 90 percent risk of death, while surgery carries a 50 percent death rate, so any alternative is welcome, he said.

He was expected to present his team's results Thursday at the annual scientific sessions of the Society for Cardiovascular Angiography and Interventions, in Orlando.

Martinez described 10 patients whose ventricular septal defects were treated at the Mayo Clinic with the patching device between 1995 and 2005. Dr. Donald J. Hagler, professor of pediatrics, also helped perform the procedures.

Five of the heart wall ruptures were caused by heart attacks, and five were unintended consequences of prior heart surgery.

Hagler used various forms of a device called the Amplatzer Occluder, manufactured by a Minnesota company, which consists of two discs connected by a thick shaft.

The device is threaded in collapsed form into the heart by a catheter and is opened at the site of the rupture in the ventricle walls. It is made of flexible nitinol metal and covered with a polyester fabric. New heart tissue can grow on this fabric, repairing the hole permanently.

Unless something is done to close the hole, blood shoots backward from the left to the right ventricle -- rather than into the body -- with each heartbeat, causing severe heart failure.

However, the device effectively closed the holes completely in 8 of the 10 cases, Martinez reported.

According to Dr. Robert Beekman III, co-director of the heart center at Cincinnati Children's Hospital Medical Center, a version of the device is now the standard of care for a related heart problem called "atrial septal defects" -- holes between the two upper chambers of the heart that can appear at birth. Beekman has implanted such devices in hundreds of children with congenital heart defects.

However, ventricular septal defects "are very different heart problems," Beekman said. The ventricular septal defect repair device used at the Mayo Clinic remains experimental, he noted.

"There is a lot more morbidity and complications [with the ventricular problem] than with atrial septal defect closure, so it is taking a lot more time for the Food and Drug Administration to approve it," Beekman said.

The procedures done for the adult heart attack patients at the Mayo Clinic were all successful, Martinez said, although one patient died five days later of an illness unrelated to the ventricular septal defect patch. Surgery was later performed successfully in the two patients where the hole remained partially open and in a third patient in whom a bacterial infection developed months later. All three of the patients survived, the researchers said.

More information

Septal defects and their treatment are described by the American Heart Association.

SOURCES: Matthew W. Martinez, M.D., cardiology fellow, Mayo Clinic, Rochester, Minn; Robert Beekman III, M.D., co-director, heart center, Cincinnati Children's Hospital Medical Center; May 10, 2007, scientific sessions, Society for Cardiovascular Angiogrphy and Interventions, Orlando, Fla.

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