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Air Pollution Poses Heart Risk to Postmenopausal Women

And the higher and longer the exposure, the bigger the threat, study finds

Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. And "More information" links may no longer work. Questions about personal health should always be referred to a physician or other health care professional.

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HealthDay Reporter

WEDNESDAY, Jan. 31, 2007 (HealthDay News) -- Postmenopausal women who live in areas with higher air pollution levels have a higher risk of developing cardiovascular disease and of dying from it.

That's the conclusion of new research that found the risk of heart disease is higher than previously thought, and there can be substantial variations within individual cities.

"The risk of having a cardiovascular event, that is, a heart attack, stroke or needing bypass surgery, or of dying of a cardiovascular cause, was increased," said study senior author Dr. Joel Kaufman, professor of environmental and occupational medicine and epidemiology at the University of Washington.

The study is the first to look at new cases of cardiovascular disease, not just death. It was also the first to look at air pollution levels within cities. The results are published in the Feb. 1 issue of the New England Journal of Medicine.

"It's an important study," said Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in New York City. "They showed that very small particulate matter can penetrate into the lungs and cause damage over time."

Fine particulate matter is comprised of tiny particles of soot or dust carried in the air. "They mostly come from combustion of fossil fuels, although vegetative burning has an impact in some cities," Kaufman said. "In the United States as a whole, we're mostly talking about power plants, coal burning and motor vehicle exhaust, especially diesel exhaust."

Cardiovascular disease is the leading cause of death in the United States, accounting for one in three deaths. Reducing fine particulate air pollution could result in less cardiovascular disease and fewer deaths, the study authors stated.

For the study, Kaufman and his colleagues looked at 65,893 postmenopausal women in 36 U.S. metropolitan regions who were part of the Women's Health Initiative, a large, government-funded study designed to look at heart health, cancer and osteoporosis in women. All participants were free of cardiovascular disease at the start of the study in 1994.

Each increase of 10 micrograms of fine particulate matter per cubic meter was associated with a 24 percent increase in the risk of a cardiovascular event and a 76 percent increase in the risk of death from cardiovascular disease.

Women having a higher long-term average exposure had a higher risk. And different health risks within cities were often larger than those between cities.

Scientists aren't sure how fine particulate air pollution increases these health risks, although it's possible that inhaling the particles may be speeding the development of atherosclerosis or hardening of the arteries.

An accompanying editorial in the journal called for better long-term environmental standards.

"The EPA [U.S. Environmental Protection Agency] did tighten 24-hour standards but failed to listen to its scientific advisers on long-term standards. They could be tightened," Horovitz said.

Kaufman added: "This is not a study that necessarily spells individual-level health decisions. It's not like we can say people should move. We really need to work harder to lower these levels, and we need to think about pollution as a risk factor, like smoking and diabetes and cholesterol. We need to think of pollution as a cause of health effects now and not just a nuisance factor and something that causes haze on the horizon."

More information

Daily pollution readings for more than 150 cities are provided by the EPA.

SOURCES: Joel D. Kaufman, M.D., professor of environmental and occupational medicine and epidemiology, University of Washington, Seattle; Len Horovitz, M.D., pulmonary specialist, Lenox Hill Hospital, New York City; Feb. 1, 2007, New England Journal of Medicine

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