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Study Links Low Vitamin D Levels to Worse MS Symptoms

But it's too soon to recommend supplements for multiple sclerosis patients, researcher says

Study Links Low Vitamin D Levels to Worse MS Symptoms

FRIDAY, Oct. 5, 2012 (HealthDay News) -- Multiple sclerosis patients with low blood levels of vitamin D have more brain lesions and signs of a more active disease state, a new study finds.

Multiple sclerosis is an autoimmune disease that damages the outside of nerve fibers in the central nervous system, according to the National Multiple Sclerosis Society. Symptoms can include fatigue, numbness in the limbs, balance and coordination problems, vision problems, pain, and even paralysis.

The new findings suggest a potential link between vitamin D intake and the risk of long-term disability from MS, according to the researchers.

They analyzed data from a five-year study of nearly 500 MS patients and found that each increase of 10 nanograms per milliliter in blood levels of vitamin D was associated with a 15 percent lower risk of new brain lesions and a 32 percent lower risk of spots of active disease.

These spots of active disease require drug treatment to reduce the risk of permanent nerve damage.

The study also found that higher vitamin D levels were associated with lower subsequent disability.

The effects of vitamin D levels remained even after the researchers accounted for other factors that can affect disease progress, such as smoking, current MS treatment, age and gender, according to the study, which was published in a recent issue of the journal Annals of Neurology.

It is too soon, however, to recommend vitamin D supplementation as a treatment, one of the study authors said.

"Even though lower levels of vitamin D are associated with more inflammation and lesions in the brain, there is no evidence that taking vitamin D supplements will prevent those symptoms," study leader Dr. Ellen Mowry, assistant professor of neurology at the Johns Hopkins University School of Medicine in Baltimore, said in a university news release.

"If we are able to prove that through our currently enrolling trial, it will change the way people with multiple sclerosis are treated," she added.

Although the study found an association between increased vitamin D levels and decreased MS symptoms, it did not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about multiple sclerosis.

SOURCE: Johns Hopkins Medicine, news release, Oct. 2, 2012
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