Acquire the license to the best health content in the world
Contact Us

Treating Tourette Syndrome

Drug relieves depression in children with disorder

THURSDAY, Dec. 19, 2002 (HealthDayNews) -- The drug mecamylamine, which blocks nicotine receptors in the brain, seems to relieve mood instability and depression in adolescents and children with Tourette Syndrome.

So says a preliminary study in the latest issue of Depression and Anxiety.

The national randomized study by University of South Florida College of Medicine researchers included 50 children and adolescents with Tourette Syndrome and at least one of several mood disorders, including depression, attention-deficit disorder, oppositional defiance disorder, obsessive compulsive disorder and hypomania.

Of the 50 study participants, 38 completed the eight-week trial -- 21 taking a placebo pill and 17 receiving mecamylamine, a drug originally used to treat hypertension.

The study found the greatest mecamylamine-related improvements in the behavioral and emotional symptoms of four Tourette's patients who also had major depression. They had significant decreases in sudden mood changes, irritability, inattention, anxiety, restlessness, impulsiveness and demanding attention.

The study participants with Tourette's and depression who received the placebo showed no improvement.

The researchers recently began a controlled study of mecamylamine in children and adolescents with bipolar disorder, also called manic depression.

More information

Here's where you can learn more about Tourette Syndrome.

SOURCE: University of South Florida College of Medicine, news release, December 2002
Consumer News