Clindamycin, TMP-SMX Linked to Better Outcomes for Abscesses

Clindamycin or trimethoprim-sulfamethoxazole ups short-term outcomes vs incision, drainage alone


FRIDAY, June 30, 2017 (HealthDay News) -- For small skin abscesses, treatment with clindamycin or trimethoprim-sulfamethoxazole (TMP-SMX) is associated with improved short-term outcomes versus incision and drainage alone, according to a study published online June 28 in the New England Journal of Medicine.

Robert S. Daum, M.D., from the University of Chicago Hospitals, and colleagues conducted a multicenter trial involving adult and children outpatients. The authors enrolled 786 patients (64.2 percent adults, 35.8 percent children) with a skin abscess of 5 cm or smaller in diameter. Participants were randomized to receive clindamycin, TMP-SMX, or placebo for 10 days after abscess incision and drainage.

The researchers found that in the intention-to-treat population, the cure rate was similar for patients in the clindamycin and TMP-SMX groups at 10 days after therapy (83.1 and 81.7 percent, respectively; P = 0.73); the cure rate in each active treatment group was higher than that seen in the placebo group (68.9 percent; both P < 0.001). The beneficial effect was limited to those with Staphylococcus aureus infection. Among those who were initially cured, at one-month follow-up, new infections were less common in the clindamycin group versus the TMP-SMX or placebo groups (6.8 versus 13.5 percent [P = 0.03] and 12.4 percent [P = 0.06], respectively). Adverse events were more frequent with clindamycin versus TMP-SMX or placebo (21.9 versus 11.1 and 12.5 percent; respectively).

"This benefit must be weighed against the known side-effect profile of these antimicrobials," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Physician’s Briefing Staff

Physician’s Briefing Staff

Published on June 30, 2017

Read this Next
About UsOur ProductsCustom SolutionsHow it’s SoldOur ResultsDeliveryContact UsBlogPrivacy PolicyFAQ