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Combination Therapy Works Best in Treating Keloids

Injections of triamcinolone and 5-fluorouracil plus laser treatments better than injections alone

MONDAY, Aug. 7 (HealthDay News) -- A combination of triamcinolone and 5-fluorouracil injections plus treatment with a pulsed-dye laser is more effective for treating keloids and hypertrophic scarring than injections alone, according to a report published in the July issue of Dermatologic Surgery.

Ali Asilian, M.D., of Isfahan University of Medical Sciences in Isfahan, Iran, and colleagues conducted a 12-week study of 69 patients who were divided into three groups: group one was given weekly intralesional injections of triamcinolone acetonide; group two was given weekly injections of triamcinolone plus the 5-fluorouracil; and group three was given both therapies plus pulsed-dye laser treatments at the first, fourth and eighth week. A blinded observer then examined the lesions.

The researchers found that all groups demonstrated acceptable improvement at the eight-week and 12-week follow-up. However, those treated with combination therapy were more likely to achieve results that were rated as good-to-excellent by the patients (20 percent in group one, 55 percent in group two and 75 percent in group three) as well as by a blinded observer (15 percent, 40 percent and 70 percent in groups one through three, respectively).

"Even though all treatment groups in our study showed an acceptable improvement in nearly all measures, these were more significant in the [triamcinolone, 5-fluorouracil, pulsed-dye laser] group. This combination was also more acceptable by the patients. Its effects on itch reduction and lightening of the lesion was promising," the authors conclude.

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